Increased Specificity, Improved Lipidomic Clarity, and Identification Confidence with SONAR

Library Number:
APNT134944356
Part Number:
720006036EN
Author(s):
Adam King, Lee A. Gethings, Robert S. Plumb, and Ian D. Wilson
Source:
Waters, Imperial College London
Content Type:
Application Notes
Content Subtype:
Technical Notes
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This study demonstrates the benefits of SONAR for omics studies, providing enhanced specificity, clearer spectra, and ultimately fewer false positives when conducting compound database searches. A comparison of SONAR with an alternative DIA methodology shows how increased specificity in the workflow can reduce false positives that result from simultaneous fragmentation from multiple species within the collision cell.


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