Orthogonal Chromatographic Techniques for the Quantitative Analysis of Potential Mutagenic Impurities

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Jennifer Simeone, Senior Scientist, Separations Technologies
Waters Corporation
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Convergence chromatography is a name sometimes given to supercritical fluid chromatography (SFC) to highlight the convergence of liquid and gas states in the mobile phase. This convergence results in a single technique that can deliver the benefits offered by both liquid chromatography (LC) and gas chromatography (GC), while avoiding some of their limitations. In GC systems, the temperature-driven separation is highly efficient, but selectivity is limited by the available column chemistries and the types of carrier gases. LC instruments, and in particular, its high pressure and ultrahigh pressure versions (HPLC and UPLC), are also highly efficient but limited by the available instrumentation, the suitability of the solvents used, and the particle size of the stationary phase.

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Orthogonal Chromatographic Executive Summary PDF 1002.09kB