DESI-Mass Spectrometry Imaging Investigation of Discrete and Cassette Drug Dosed Tissues

Library Number:
APNT134934269
Part Number:
720005947EN
Author(s):
Philippa J Hart, Mark Towers, Emmanuelle Claude, and Michael Batey
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Technical Notes
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In this technology brief desorption electrospray ionization (DESI) mass spectrometry imaging (MSI) was used to analyse tissue sections from cassette dosed drug metabolism and pharmacokinetic (DMPK) models. The ability to map the distribution of drugs and their metabolites in the liver, alongside endogenous lipid species is demonstrated.


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