Screening for a Panel of 12 Toxicologically-Relevant Drugs in Urine using Tof-MRM

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Jeff Goshawk and Michelle Wood
Content Type:
Application Notes
Content Subtype:
Technical Notes
Related Products:
Forensic Toxicology

Here we describe the application of Tof-MRM using a Xevo® G2-XS QTof with UNIFI® Scientific Information System for the analysis of forensically-relevant drugs in urine.

Tof-MRM has been successfully used, on the Xevo G2-XS QTof, to analyze a panel of 12 drug substances. The enhanced selectivity of Tof- MRM permitted detection of the analytes in urine spiked at low ng/mL concentrations and prepared by a simple dilution.

Tof-MRM combined with the ability to perform Tof-MSE enables comprehensive non-targeted screening and confirmation on a single platform.

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