Determination of Urinary Opioids by Solid-phase Extraction LC-MS/MS for Clinical Research: Comparison of Automated and Manual Sample Preparation

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Teresa Pekol, Jonathan Danaceau, Sherri Naughton and Kendon Graham
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The aim of this study was to compare the performance and benefits of automated sample preparation using a Tecan Freedom EVO® 100 liquid handler to manual sample preparation in the context of a routine clinical research application. For the determination of a panel of 21 opioids in human urine by solid-phase extraction (SPE) LC-MS/MS, manual and automated sample preparation runs were performed on each of three days to compare linearity, precision, accuracy, carryover, and sample preparation time.

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