Rapid, Simple, and Effective Clean-up of Bovine Liver Samples Prior to UPLC-MS/MS Multiresidue Veterinary Drugs Analysis

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Michael S. Young and Kim Van Tran
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In this study a novel reversed-phase sorbent, Oasis PRiME HLB, is used for highly effective removal of both phospholipids and fats from bovine liver extracts prior to LC-MS/MS analysis. With the new sorbent recoveries of veterinary drugs were similar to results obtained using C18 for clean-up. However, greater than 95% of phospholipids and greater than 85% of fats were effectively removed from the tissue extracts after the simple pass-through SPE procedure.

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