The Direct Quantification of a Mutagenic Impurity, Methyl Amino Crotonate, Using ACQUITY UPC2 and QDa Detector

Library Number:
APNT134919219
Part Number:
720005846EN
Author(s):
Janet Hammond and Mark Wrona
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Application Notes
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This application note discusses the work carried out to investigate the use of Waters® UltraPerformance Convergence Chromatography™ (UPC2) and MS detection using the ACQUITY QDa as an alternative technology for the analysis of MAC (Methyl-3-aminocrotonate) without the prior need of derivatization, for the detection and quantification in an active pharmaceutical ingredient (API).


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