Coupling Mass Detection with UV to Improve Method Sensitivity for Esters of Benzenesulfonic Acid in Analysis of Genotoxic Impurities

Library Number:
APNT134890242
Part Number:
720005680EN
Author(s):
Margaret Maziarz and Mark Wrona
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Application Notes
Related Products:
 
 
 

In this application note, we present a robust and quick UPLC method for analysis of methyl, ethyl, and isopropyl esters of benzenesulfonic acid.

The ACQUITY UPLC H-Class System, coupled with the ACQUITY UPLC PDA and ACQUITY QDa detectors, provides an excellent solution for monitoring potential genotoxic impurities with accurate confirmation and quantitation.

Overall, the ACQUITY QDa Detector is a robust and simple-to-use detector that can be added as an orthogonal detection technique to UV detection. It provides accurate and reliable results, making this technology ideal for routine testing of pharmaceutical products in the QC laboratory.


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