USP Method Modernization Using “Equivalent L/dp” and “Equivalent N” Allowed Changes with CORTECS C8 and CORTECS UPLC C8 Columns

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Thomas Swann and Jennifer M. Nguyen
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Application Notes
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This application illustrates two approaches for making allowed changes to an isocratic USP method involving modern column particles such as that found in solid-core CORTECS Columns.

Using the “equivalent L/dp” guideline is an easy way to modernize a USP method and greatly improve the speed of analysis. With the “equivalent N” guideline, the analyst can realize still further analysis speed improvements from even shorter, highly efficient columns in the CORTECS family.


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