Small Molecule Analysis

Chemists in small molecule pharmaceutical drug discovery, development, and manufacturing/QA/QC labs rely on Waters technologies to analyze more compounds with better and faster results.

Whether that means optimizing your current laboratory output, or implementing a scalable and forward-looking solution that empowers you to achieve the innovation, productivity, and profitability goals that define your success, Waters works with you every step of the way.

Explore our laboratory solutions for small molecule analysis including sample preparation, chromatography, mass spectrometry, software, and informatics, compliance, applications expertise, and support services.


Medicinal Chemistry Analytical solutions that streamline the beginning of the journey of the molecule: confirming the identity and quality of new chemical entities.
Impurity Profiling with HRMS UPLC with HRMS is a powerful tool for high-resolution characterization and quantification of active pharmaceutical ingredients (APIs) and their related impurities.
DMPK: Drug Metabolism and Pharmacokinetics A portfolio of solutions to support the pharmaceutical research and development, focusing on drug metabolism and pharmacokinetics (DMPK).
Small Molecule Method Development Labs are under pressure to improve analytical methods development processes that support tasks from scouting to stability testing. Waters technologies will radically upgrade your efficiency in method development.
Natural Products & Traditional Medicines A portfolio of solutions to support the medicinal and therapeutic natural products development process.
Quality Control/Quality Assurance (QA/QC) To manufacture safe and effective drugs, labs critically analyze raw materials, process products, and final pharmaceutical products. Waters LC is used reliably in QA/QC labs to ensure purity and to measure stability over a drug’s intended shelf life.
Generic Pharmaceuticals Generic Pharmaceutical companies around the world are taking advantage of the ability to convert HPLC methods to UPLC, to get drugs to market faster, while ensuring quality of their end product.
Regulated Bioanalysis Platform Solution with UNIFI Today's most advanced technology for regulated bioanalysis is also tomorrow's most advanced technology for regulated bioanalysis.
Metabolite Identification Application Solution with UNIFI Identify and characterize metabolites in both discovery and development better and faster than ever before. UPLC/QTof with fit-for purpose software, methods, chemistries, standards, and reagents for a new standard of what's possible in metabolite ID.
Natural Products Application Solution with UNIFI The Waters Natural Products Application Solution with UNIFI combines UPLC/QTof MS analytical technology with UNIFI informatics and a Traditional Medicines Library to streamline the identification of chemical structures in complex natural products.

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