The XBridge™ column family is designed for maximum method development flexibility. Develop robust methods across the entire pH spectrum using an unparalleled range of mobile phases and temperatures. For isolation and purification, the high pH stability of XBridge Prep OBD™ columns allows for purer fractions and increased mass loading for bases.
XBridge columns provide consistent performance and extended lifetime under even the most demanding conditions. Developed with revolutionary technology and the highest levels of manufacturing and quality assurance, they are a trusted solution for your most challenging chromatographic separations.
With a selection of 10-general-purpose and application-specific sorbents in the widest range of particle sizes, no other HPLC column family provides the necessary tools for the most demanding chromatographic challenges. Whether you require robust HPLC methods, seamless UPLC® tranferability, or preparative scaling for product isolation, you can count on the versatility of XBridge™ columns.
XBridge™ columns are the most pH stable high-performance chromatographic phases commercially available. Unlike approaches that claim high-pH resistance due to special surface modifications, XBridge columns have stability built in as part of the particle synthetic process.
Under accelerated pH 10 stability test conditions, a direct comparison (using some of the most popular chromatographic phases that claim extended high-pH stability) clearly shows that the XBridge C18 column lifetime exceeds that of the best silica column by over 1000% -- with very little degradation in chromatographic performance.
Accelerated High pH Stability Test of Competitive Columns
Chromatograms, run at regular intervals during the high-pH lifetime study, verify that 86% of the original XBridge column efficiency remains after 300 hours of pH 10 and elevated temperature, with little change in peak shape or retention time.
Created with identical manufacturing processes, XBridge™ and ACQUITY UPLC® columns’ BEH Technology™ materials differ only by particle size, allowing for seamless methods transfer and the fastest route to an optimized LC method.
You need no longer choose between HPLC and UPLC® technologies. The BEH particle used in XBridge and ACQUITY UPLC columns:
HPLC Chromatographic Conditions
Based upon identical manufacturing processes, XBridge and ACQUITY® BEH Technology materials differ only by particle size allowing for seamless transfer of methods and the fastest route to an optimized LC method.
The combination of the rugged XBridge™ packings and the OBD™ design ensures direct scalability, maximum efficiencies and the longest column lifetimes.
Preparative packing materials routinely feature a much wider particle size distribution than the equivalent analytical particle. While this approach reduces the cost of material manufacturing, the chromatographic performance is almost certainly compromised.
XBridge Prep packing materials are fully optimized to deliver maximum efficiency and the highest loadability at the lowest possible back-pressures. These attributes give you the flexibility to choose the best combination of particle size and column dimension to easily purify even the most complex samples.
Maximum Efficiency/30% Lower Backpressure
The XBridge™ family of columns is characterized by a strong level of chromatographic performance and confidence. You can achieve robust, rugged methods across the entire pH range of 1-12, simplifying the validation and method transfer process.
Utilizing a sample method development protocol consisting of XBridge columns, two mobile phase pHs, and two organic solvents, even the most challenging sample mixtures can be quickly resolved.
Efficient Method Development
Efficient Method Development