UPLC® Technology was created especially for scientists who seek proven, reliable technology that simultaneously improves laboratory productivity, efficiency, and throughput. With its success demonstrated by thousands of peer-reviewed papers and application notes, and dramatic process improvements, leading companies and institutions around the world have standardized on UPLC for measurable scientific and business benefits.

ACQUITY H-Class QDa System ACQUITY QDa Detector - Effortless Integration The ACQUITY QDa Detector is the mass detector designed to be a synergistic element of your chromatographic separations system and will seamlessly integrate with your current LC, UPLC, UPC2, and purification systems.
ACQUITY UPLC M-Class System ACQUITY UPLC M-Class System The most reliable and highest performing nano- to microscale instrument available to deliver UPLC-quality (UHPLC) separations ― providing more sensitivity to every laboratory performing LC-MS analyses.
ACQUITY UPLC I-Class System The highest performing UPLC/UHPLC system ever engineered. With dramatically decreased dispersion for the highest resolution, rapid injection cycles and sample throughput with reduced carryover, it's clearly the superior inlet to any mass spectrometer.
ACQUITY UPLC System ACQUITY UPLC System The ACQUITY UPLC System lets you achieve higher UPLC/UHPLC chromatographic resolution and sensitivity and greater throughput using sub-2-µm particle technology. This is the original UPLC system featuring binary solvent management.
ACQUITY UPLC H-Class ACQUITY UPLC H-Class System The ACQUITY UPLC H-Class System is the first UPLC/UHPLC system that delivers the flexibility of quaternary solvent blending with the advanced performance expected of UPLC separations: high resolution, sensitivity and improved throughput.
ACQUITY UPLC H-Class Bio ACQUITY UPLC H-Class Bio Engineered with a bio-inert flow path, the ACQUITY UPLC H-Class Bio System is ideal for orthogonal RP, SEC, IEX, and HILIC quaternary bioseparations.
ACQUITY UPLC Online SPE Anaylzer ACQUITY UPLC Automated SPE System ACQUITY UPLC Automated SPE System utilizes advanced fluidics and a Solid Phase Extraction (SPE) cartridge technology to seamlessly integrate SPE sample preparation with UPLC/MS analysis in a single platform.
ACQUITY Systems with 2D Technology ACQUITY UPLC Systems with 2D LC Technology ACQUITY UPLC Systems with 2D LC/multidimensional LC provide resolution, sensitivity, and productivity for multidimensional applications that is simple to use, easy to implement, and compatible with a wide range of chemistries.
PATROL UPLC Process Analysis System PATROL UPLC Process Analysis System Bringing chromatographic analysis to process analytical technology (PAT), this real-time UPLC system is able to detect and quantify complex multiple component samples and final product.
Open Architecture UPLC System Open Architecture UPLC Robust UPLC analyses in a familiar workflow for chemists in discovery laboratories are available with the Open Architecture UPLC System’s flat-bed sample manager and open-access software.
UPLC with On-line SPE Technology Streamlines the analysis of drinking water samples by providing analyte extraction, clean-up, concentration, separation, and detection in one turn-key solution.
ACQUITY UPLC Detectors Optical and mass detectors are optimized for UltraPerformance LC separations, with low dispersion characteristics, performance, and high data-acquisition rates.
ACQUITY UPLC Accessories Accessories for the ACQUITY UPLC System allow you to customize instrument performance by managing column temperature, number of columns, and quantity of samples needed to analyze. The cart provides easy mobility.
Auto•Blend Plus Auto•Blend Plus automates the formulation of mobile phases from reservoirs of pure solvents or concentrated stock solutions. It comes with an ACQUITY UPLC H-Class or H-Class Bio System.
ACQUITY UPLC M-Class System w/HDX Technology ACQUITY UPLC M-Class System with HDX Technology The ACQUITY UPLC M-Class System w/Hydrogen Deuterium Exchange (HDX) Technology and high-resolution MS identifies changes in protein conformation with confidence by stringently controlling temperature sensitive parts of the HDX sample work up.
ACQUITY UPLC M-Class System w/2D Technology ACQUITY UPLC M-Class System with 2D Technology For protein identifications, quantification, and sequence coverage, 2D technology employs reversed-phase chromatography at pH 10 in the first dimension, followed by reversed-phase chromatography at pH 2 in the second dimension.

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Columns for chiral separations now available from Waters
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