Realize the benefits of switching to SFE technology for the extraction, fractionation, and isolation of chemical compounds:
Increasing concern about the quality, safety, usage, and disposal of hydrocarbon based solvents as well as stricter regulations on the residual levels of solvents have all contributed to many industries switching to SFE technology for the extraction, fractionation, and isolation of chemical compounds.
Using carbon dioxide
Waters Prep Supercritical Fluid Extraction (SFE) systems extract chemical compounds using CO2 in its supercritical state in place of organic solvents. The result is an extract with little or no residual solvent, superior purity, selectivity, yield, and lower operating costs when compared to solvent-based systems. SFE provides a faster, safer, and cleaner technology for applications such as:
The biggest advantage of SFE is that it leaves no traces in the product. After extraction, the carbon dioxide is either depressurized and vented, or recycled for further extraction use. Any residual trace of carbon dioxide in the product dissipates into the atmosphere within a few hours. As a tunable solvent, CO2 is nontoxic, nonflammable, and physiologically compatible.
Waters preparative SFE systems come in a variety of sizes to meet your needs. The size of the main extraction vessel can be 100mL, 500mL, 1000mL, 2000mL, or 5000mL. The systems also offer many options.
System options include:
Waters SFE systems extract chemical compounds using supercritical CO2 instead of an organic solvent. The supercritical fluid state occurs when a fluid is above its critical temperature and critical pressure. This supercritical state allows CO2 to take on properties of a gas (high diffusivity, low surface tension) as well as maintaining the solvating power of a liquid.
Manipulating the temperature and pressure of CO2 alters the solvent power and allows the material of interest to be selectively extracted. The sample is placed in an extraction vessel and pressurized with CO2 to extract the compound of interest. (As supercritical CO2 will only extract non-polar compounds, a small percentage of co-solvent can be added to extract polar compounds.) This compound is then transferred from the extraction vessel to a fraction collector. The back pressure regulator located between these vessels allows for controlled depressurization of the compounds of interest and the CO2. At the exit of the BPR, the system pressure is reduced to near atmospheric conditions causing the CO2 to lose its solvating power and the extracted material precipitates out of solution into the fraction collector. The condensed CO2, now a gas, is sent to vent or can be recycled.