Hydrogen Deuterium Exchange with Mass Spec (HDX MS)

Answers for all of your structural questions

For higher order structure studies, hydrogen deuterium exchange with mass spectrometry – alternatively referred to as H/D exchange, HDX, or HXMS – has become indispensable for biotech companies.

Recent innovations in LC/MS, automation, and informatics technologies have converted HDX MS from a complex academic exercise to a robust tool for discovery and development of protein drugs.

  • Overview
  • Related
  • Literature
  • Application Notes
What is MSE?

MSE is the ultimate technology for comprehensive, reproducible profiling and characterization.
Learn more.

Article reprint

"Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars" by HDX thought leaders Steven Berkowitz and John Engen.
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Center of Innovation

Professor John Engen at Northeastern University is a pioneer in the use of hydrogen deuterium exchange and ion mobility mass spectrometry, HDX MS.
Learn about Dr. Engen's lab

Customer video

Rachel Garlish of UCB discusses how Waters's HDX solution gives her insights to the molecules she's investigating - and fast answers.
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