nanoACQUITY Columns and trap columns are the previous generation of columns for nano- and microflow LC-MS applications. They are being replaced by the new generation of ACQUITY UPLC M-Class columns:
Waters recommends switching from the previous generation of nanoACQUITY columns to the new-designed M-Class columns. AQUITY UPLC M-Class columns for nano-and micro-flow LC-MS are compatible with nanoACQUITY UPLC’s and are available with the same sub-2-µm stationary phases for peptide- and protein LC-MS separations.
Waters provides a cross reference table to easily find the equivalent M-Class column part number.