Supercritical CO2 Based Technologies (SFx)

Discover the Future of Supercritical CO2 Based Technologies

Supercritical CO2 based technologies have been shown to reduce costs and increase efficiency when applied to diverse sample types with the widest selectivities from polar to non-polar.

Waters SFx Portfolio offers a range of supercritical CO2 based technologies from extraction to analysis to purification, Waters is driving the future of SFx.


When used for Botanical extractions the use of Food grade CO2 allows clean, safe and tunable extractions as cost effective alternatives to organic solvent and other fluid based extractions.


Supercritical CO2 based technologies generate robust, reproducible results for a wide range of chiral and achiral compounds on the same analytical system. This technology has been shown to increase efficiency, use less solvent and lower costs while being fully compatible with the full range of Waters mass spectrometers.


Preparative SFC Technologies utilize liquid CO2, a faster, eco-friendly alternative to traditional solvents, decreasing your overall solvent purchase and disposal costs as well as faster fraction processing. Preparative SFC allows operational flexibility between chiral and achiral compound classes with simple mobile phase choices. Mass directed isolation is simplified with the easy to use ACQUITY QDa Mass Detector.

ACQUITY UPC2 System Built upon proven UPLC Technology to enable scientists the ability to address routine and complex separation challenges while delivering reliability, robustness, sensitivity, and throughput never before possible.
SFC Columns SFC column technology for chiral and achiral separations with Torus, Trefoil and Viridis columns brought to you by Waters.
Supercritical Fluid Extraction (SFE) Systems Supercritical Fluid Extraction (SFE) Systems provide solvent-free extraction, fractionation, and isolation of chemical antioxidant compounds.
Supercritical Fluid Chromatography Supercritical fluid chromatography (SFC) is an environmentally-friendly approach to analytical and purification applications.
UPC2 Columns

Columns for chiral separations now available from Waters
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Cosmetics & Toiletries Hosted Webinar:

Supercritical CO2 to Support the Research & Development of Cosmetic Products
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